Role of Coriandrum Sativum in Gastric Ulcer

The present study was undertaken to evaluate the anti-ulcerogenic effect of Coriandrum sativum Linn. in experimental animals. The study was carried out on stress as well as on chemically induced gastric ulcer models. Hydroalcoholic extract of Coriander seeds was used for the study. The animals were divided into different groups to evaluate both preventive and curative effect of the test drug. The two parameters viz. ulcer score and ulcer index were taken to assess the anti-ulcerogenic effect. Histopathological studies were also carried out to determine the nature as well as the degree of damage and the comparative improvement, if any. The effect produced by different groups was tabulated and analyzed statistically by Kruskal-Wallis post hoc Dunn’s multiple pair comparison test. It can be concluded that the test drug possesses significant anti-ulcer activity against stress and aspirin-induced ulcer. Its effect mediated through anti-stress mechanism is remarkable. The curative effect is more pronounced than the preventive effect and the higher dose is almost as effective as the standard drug ranitidine.